• Product NameCHIR-99021
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityCHIR-99021 (CT99021) is a GSK-3α and GSK-3β inhibitor with IC50 of 10 nM and 6.7 nM, respectively.
• Target NameGSK-3 inhibitor
• CAS No. 252917-06-9
• Calculated MW 465.34
• Formulation C22H18Cl2N8
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:CC1=CN=C(N1)C1=CN=C(NCCNC2=NC=C(C=C2)C#N)N=C1C1=C(Cl)C=C(Cl)C=C1
  Pathways:PI3K/Akt/mTOR signaling; Stem Cells
  Receptor:GSK-3α; GSK-3β
  Boling pt:
  Melting pt:
  Solubility:DMSO: 78 mg/mL warmed (167.61 mM)
  Appearance:YellowPowder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Naujok O, et al. BMC Res Notes. 2014 Apr 29;7:273. 2. Besing RC, et al. J Biol Rhythms. 2015 Apr;30(2):155-60.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting