• Product NameLDC1267
• Brief DescriptionInhibitors
• Purification99.44%
• Biological ActivityLDC1267 is a highly selective TAM kinase inhibitor with IC50 of <5 nM, 8 nM, and 29 nM for Mer, Tyro3, and Axl, respectively. Displays lower activity against Met, Aurora B, Lck, Src, and CDK8.
• Target NameTAM Receptor inhibitor
• CAS No. 1361030-48-9
• Calculated MW 560.55
• Formulation C30H26F2N4O5
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CCOC1=CN(N=C1C(=O)NC1=CC(F)=C(OC2=C3C=C(OC)C(OC)=CC3=NC=C2)C=C1)C1=C(C)C=C(F)C=C1
  Pathways:Tyrosine Kinase/Adaptors
  Receptor:AXL; Mer; Tyro3
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 2 mg/mL warmed (3.56 mM); DMSO: 100 mg/mL warmed (178.39 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Paolino M, et al. Nature. 2014, 507(7493), 508-512.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting