• Product NamePF 431396
• Brief DescriptionInhibitors
• Purification98.48%
• Biological ActivityPF-431396 is a dual PYK2/FAK inhibitor with IC50 of 11 nM and 2 nM, respectively.
• Target NameFAK inhibitor; PYK2 inhibitor
• CAS No. 717906-29-1
• Calculated MW 506.5
• Formulation C22H21F3N6O3S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:CN(C1=CC=CC=C1CNC1=NC(NC2=CC3=C(NC(=O)C3)C=C2)=NC=C1C(F)(F)F)S(C)(=O)=O
  Pathways:Angiogenesis; Tyrosine Kinase/Adaptors; Cytoskeletal Signaling
  Receptor:FAK; PYK2
  Boling pt:
  Melting pt:
  Solubility:DMSO: 100 mg/mL (197.43 mM)
  Appearance:Silver Gray Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Han S, et al. J Biol Chem. 2009, 284(19), 13193-13201.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting