• Product NameAcotiamide hydrochloride
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityAcotiamide Hydrochloride is the hydrochloride salt form of acotiamide, a prokinetic agent with gastrointestinal (GI) motility-enhancing activity. Although the exact mechanism by which acotiamide exerts its effect has yet to be fully elucidated, this agent appears to inhibit acetylcholinesterase (AchE), an enzyme responsible for the breakdown of acetylcholine (Ach). Increased Ach concentrations lead to an improvement of gastric emptying and GI motility and eventually to a reduction of dyspepsia symptoms.
• Target NameAChR inhibitor
• CAS No. 773092-05-0
• Calculated MW 541.06
• Formulation C21H37ClN4O8S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Metabolism system
  SMILES:O.O.O.Cl.COC1=C(OC)C=C(C(=O)NC2=NC(=CS2)C(=O)NCCN(C(C)C)C(C)C)C(O)=C1
  Pathways:Neuroscience
  Receptor:AChE
  Boling pt:
  Melting pt:
  Solubility:DMSO: 10 mM
  Appearance:White Crystal
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Kawachi M,et al. Eur J Pharmacol. 2011 Sep;666(1-3):218-25.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting