• Product NameTolvaptan
• Brief DescriptionInhibitors
• Purification97.00%
• Biological ActivityTolvaptan is an orally effective nonpeptide arginine vasopressin V2 receptor antagonist with IC50 of 3 nM, used to treat hyponatremia.
• Target NameVasopressin Receptor antagonist
• CAS No. 150683-30-0
• Calculated MW 448.94
• Formulation C26H25ClN2O3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cardiovascular System
  SMILES:CC1=CC=CC=C1C(=O)NC1=CC(C)=C(C=C1)C(=O)N1CCCC(O)C2=C1C=CC(Cl)=C2
  Pathways:GPCR/G Protein
  Receptor:vasopressin receptor 1a; vasopressin receptor 2
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 6 mg/mL (13.36 mM); DMSO: 90 mg/mL (200.47 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Miyazaki T, et al. Cardiovasc Drug Rev, 2007, 25(1), 1-13.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting