• Product NamePelitinib (EKB-569)
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityPelitinib (EKB-569) is a potent irreversible EGFR inhibitor with IC50 of 38.5 nM. Phase2.
• Target NameEGFR inhibitor; MEK inhibitor; Raf inhibitor; Src inhibitor
• CAS No. 257933-82-7
• Calculated MW 467.92
• Formulation C24H23ClFN5O2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CCOC1=C(C=C2C(=C1)N=CC(=C2NC3=CC(=C(C=C3)F)Cl)C#N)NC(=O)/C=C/CN(C)C
  Pathways:Angiogenesis; MAPK; JAK/STAT signaling; Tyrosine Kinase/Adaptors
  Receptor:EGFR; HER2/ErbB2; MEK; Raf; Src
  Boling pt:
  Melting pt:
  Solubility:DMSO: 13 mg/mL (27.78 mM)
  Appearance:Off-white Color Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Torrance CJ, et al. Nat Med, 2000, 6(9), 1024-1028.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting