• Product NameDolutegravir sodium(GSK1349572)
• Brief DescriptionInhibitors
• Purification99.74%
• Biological ActivityDolutegravir sodium salt(DTG; GSK1349572) is a HIV integrase inhibitor(IC50= 2.7 nM), modest activity against raltegravir-resistant signature mutants Y143R, Q148K, N155H, and G140S/Q148H.
• Target NameHIV Protease inhibitor
• CAS No. 1051375-19-9
• Calculated MW 441.36
• Formulation C20H18F2N3NaO5
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Immunology
  SMILES:C[C@@H]1CCO[C@@H]2N1C(=O)C3=C(C(=O)C(=CN3C2)C(=O)NCC4=C(C=C(C=C4)F)F)[O-].[Na+]
  Pathways:Microbiology&virology; Proteases/Proteasome
  Receptor:HIV integrase
  Boling pt:
  Melting pt:
  Solubility:DMSO: 200 mM
  Appearance:Yellow Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Kobayashi M, et al. Antimicrob Agents ChemOthers. 2011, 55(2), 813-821.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting