• Product NameAvanafil
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityAvanafil is a highly selective PDE5 inhibitor with IC50 of 5.2 nM, >121-fold selectivity over other PDEs.
• Target NamePDE inhibitor
• CAS No. 330784-47-9
• Calculated MW 483.95
• Formulation C23H26ClN7O3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Endocrine system
  SMILES:COC1=C(C=C(C=C1)CNC2=NC(=NC=C2C(=O)NCC3=NC=CC=N3)N4CCC[C@H]4CO)Cl
  Pathways:Metabolism
  Receptor:PDE5
  Boling pt:
  Melting pt:
  Solubility:DMSO: 97 mg/mL (200.43 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Kotera J, et al. J Urol. 2012, 188(2), 668-674.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting