• Product NameARN-509
• Brief DescriptionInhibitors
• Purification97.00%
• Biological ActivityARN-509 is a selective and competitive androgen receptor inhibitor with IC50 of 16 nM in a cell-free assay, useful for prostate Y treatment. Phase 3.
• Target NameAndrogen Receptor inhibitor; GABA Receptor inhibitor
• CAS No. 956104-40-8
• Calculated MW 477.43
• Formulation C21H15F4N5O2S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CNC(=O)C1=C(F)C=C(C=C1)N1C(=S)N(C(=O)C11CCC1)C1=CN=C(C#N)C(=C1)C(F)(F)F
  Pathways:Membrane transporter/Ion channel; Endocrinology/Hormones; Neuroscience
  Receptor:Androgen Receptor; GABAR
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 5 mg/mL (10.47 mM); DMSO: 18 mg/mL (37.7 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Clegg NJ, et al. Y Res, 2012, 72(6), 1494-1503.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting