• Product NameKW2449
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityKW-2449 is a multiple-targeted inhibitor, mostly for Flt3 with IC50 of 6.6 nM, modestly potent to FGFR1, Bcr-Abl and Aurora A; little effect on PDGFRβ, IGF-1R, EGFR.
• Target NameAurora Kinase inhibitor; Bcr-Abl inhibitor; c-Kit inhibitor; FGFR inhibitor; FLT inhibitor; JAK inhibitor; Src inhibitor
• CAS No. 1000669-72-6
• Calculated MW 332.4
• Formulation C20H20N4O
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:C1CN(CCN1)C(=O)C2=CC=C(C=C2)/C=C/C3=NNC4=CC=CC=C43
  Pathways:Angiogenesis; Cell Cycle/Checkpoint; Tyrosine Kinase/Adaptors; Chromatin/Epigenetic; Cytoskeletal Signaling; JAK/STAT signaling; Stem Cells
  Receptor:Aurora A; Abl; Abl (T315I); Kit; FGFR1; FLT3; FLT3 (D835Y); JAK2; Src
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 67 mg/mL (201.56 mM); DMSO: 67 mg/mL (201.56 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Shiotsu Y, et al. Blood, 2009, 114(8), 1607-17.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting