• Product NamePTC-209
• Brief DescriptionInhibitors
• Purification97.00%
• Biological ActivityPTC-209 is a potent and selective BMI-1 inhibitor with IC50 of 0.5 μM in HEK293T cell line, and results in irreversible reduction of Y-initiating cells (CICs).
• Target NameBMI-1 inhibitor
• CAS No. 315704-66-6
• Calculated MW 495.19
• Formulation C17H13Br2N5OS
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:COC1=CC(Br)=C(NC2=NC(=CS2)C2=C(C)N=C3N=CC=CN23)C(Br)=C1
  Pathways:Others
  Receptor:BMI-1
  Boling pt:
  Melting pt:
  Solubility:DMSO: 99 mg/mL (199.92 mM)
  Appearance:Yellowish-brown Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Kreso A, et al. Nat Med. 2014, 20(1), 29-36.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting