• Product NameBLU9931
• Brief DescriptionInhibitors
• Purification96.96%
• Biological ActivityBLU9931 is the first selective small molecule inhibitor of FGFR4 with IC50 of 3 nM; less potent for FGFR1/2/3(IC50> 150 nM).
• Target NameFGFR inhibitor
• CAS No. 1538604-68-0
• Calculated MW 509.38
• Formulation C26H22Cl2N4O3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:COC1=CC(OC)=C(Cl)C(=C1Cl)C1=CC2=CN=C(NC3=C(C)C=CC=C3NC(=O)C=C)N=C2C=C1
  Pathways:Angiogenesis; Tyrosine Kinase/Adaptors
  Receptor:FGFR1; FGFR2; FGFR3; FGFR4
  Boling pt:
  Melting pt:
  Solubility:DMSO: 4 mg/mL warmed (7.85 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Hagel M, et al. Y Discov. 2015 Apr;5(4):424-37.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting