• Product NameGSK2334470
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityGSK2334470 is a novel PDK1 inhibitor with IC50 of ~10 nM in a cell-free assay, with no activity at other close related AGC-kinases.
• Target NamePDK inhibitor
• CAS No. 1227911-45-6
• Calculated MW 462.59
• Formulation C25H34N8O
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:C[C@@H]1CC[C@@H](CN1C2=NC(=NC(=C2)C3=CC4=C(C=C3)C(=NN4)N)NC)C(=O)NC5CCCCC5
  Pathways:PI3K/Akt/mTOR signaling
  Receptor:PDK1
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 90 mg/mL (194.55 mM); DMSO: 90 mg/mL (194.55 mM)
  Appearance:Yellow Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Najafov A, et al. Biochem J, 2011, 433(2), 357-369.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting