• Product NameBMS-754807
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityBMS-754807 is a potent and reversible inhibitor of IGF-1R/InsR with IC50 of 1.8 nM/1.7 nM in cell-free assays, less potent to Met, Aurora A/B, TrkA/B and Ron, and shows little activity to Flt3, Lck, MK2, PKA, PKC etc. Phase 2.
• Target Namec-Met/HGFR inhibitor; IGF-1R antagonist; Trk receptor inhibitor
• CAS No. 1001350-96-4
• Calculated MW 461.49
• Formulation C23H24FN9O
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:C[C@]1(CCCN1C2=NN3C=CC=C3C(=N2)NC4=NNC(=C4)C5CC5)C(=O)NC6=CN=C(C=C6)F
  Pathways:Tyrosine Kinase/Adaptors
  Receptor:Met; IGF-1R; Insulin Receptor; TrkA; TrkB
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 92 mg/mL (199.35 mM); DMSO: 92 mg/mL (199.35 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Carboni JM, et al. Mol Y Ther, 2009, 8(12), 3341-3349.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting