• Product NameTAK875
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityTAK-875 is a selective GPR40 agonist with EC50 of 14 nM in human GPR40 expressing CHO cell line, 400-fold more potent than oleic acid.
• Target NameGPR agonist
• CAS No. 1000413-72-8
• Calculated MW 524.63
• Formulation C29H32O7S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Endocrine system
  SMILES:CC1=CC(=CC(=C1C2=CC(=CC=C2)COC3=CC4=C(C=C3)[C@@H](CO4)CC(=O)O)C)OCCCS(=O)(=O)C
  Pathways:Endocrinology/Hormones
  Receptor:GPR40(FFA1)
  Boling pt:
  Melting pt:
  Solubility:DMSO: 100mg/mL
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Nobuyuki Negoro, et al. ACS Med Chem Lett, 2010, 1(6), 290-294.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting