• Product NameAMI-1
• Brief DescriptionInhibitors
• Purification99.90%
• Biological ActivityAMI-1 is a potent and specific Histone Methyltransferase (HMT) inhibitor with IC50 of 3.0 μM and 8.8 μM for yeast Hmt1p and human PRMT1, respectively.
• Target NameHistone Methyltransferase inhibitor
• CAS No. 20324-87-2
• Calculated MW 548.45
• Formulation C21H14N2Na2O9S2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:O=C(NC1=CC(C=C(S(=O)([O-])=O)C=C2[O-])=C2C=C1)NC3=CC4=C(C([O-])=CC(S(=O)([O-])=O)=C4)C=C3.[Na+].[Na+].[Na+].[Na+]
  Pathways:Chromatin/Epigenetic
  Receptor:PRMT1; yeast Hmt1p
  Boling pt:
  Melting pt:
  Solubility:Water: 10 mg/mL (18.23 mM); DMSO: 100 mg/mL warmed (182.33 mM)
  Appearance:Gray Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Cheng D, et al. J Biol Chem. 2004, 279(23), 23892-23899.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting