• Product NameGSK-1059615
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityGSK1059615 is a dual inhibitor of PI3Kα/β/δ/γ (reversible) and mTOR with IC50 of 0.4 nM/0.6 nM/2 nM/5 nM and 12 nM, respectively.
• Target NamemTOR inhibitor; PI3K inhibitor
• CAS No. 958852-01-2
• Calculated MW 333.36
• Formulation C18H11N3O2S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:C1=CC2=NC=CC(=C2C=C1/C=C\3/C(=O)NC(=O)S3)C4=CC=NC=C4
  Pathways:PI3K/Akt/mTOR signaling
  Receptor:mTOR; PI3Kα; PI3Kβ; PI3Kγ; PI3Kδ
  Boling pt:
  Melting pt:
  Solubility:DMSO: 2 mg/mL (5.99 mM)
  Appearance:Yellow Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Maira SM, et al. Curr Top Microbiol Immunol, 2010, 347, 209-239.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting