• Product NameBaricitinib?(Phosphate)
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityBaricitinib phosphate(INCB 028050; LY 3009104) is a selective JAK1 and JAK2 inhibitor with IC50 of 5.9 nM and 5.7 nM, ~70 and ~10-fold selective versus JAK3 and Tyk2, no inhibition to c-Met and Chk2.
• Target NameJAK inhibitor; Tyrosine Kinases inhibitor
• CAS No. 1187595-84-1
• Calculated MW 469.41
• Formulation C16H20N7O6PS
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:OP(O)(O)=O.CCS(=O)(=O)N1CC(CC#N)(C1)N1C=C(C=N1)C1=C2C=CNC2=NC=N1
  Pathways:Angiogenesis; Proteases/Proteasome; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
  Receptor:JAK1; JAK2; JAK3; Tyk2
  Boling pt:
  Melting pt:
  Solubility:200 mM in DMSO
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Fridman JS, et al. J Immunol, 2010, 184(9), 5298-5307.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting