• Product NameLY-2874455
• Brief DescriptionInhibitors
• Purification99.46%
• Biological ActivityLY2874455 is a pan-FGFR inhibitor with IC50 of 2.8 nM, 2.6 nM, 6.4 nM, and 6 nM for FGFR1, FGFR2, FGFR3, and FGFR4, respectively, and also inhibits VEGFR2 activity with IC50 of 7 nM. Phase 1.
• Target NameFGFR inhibitor; VEGFR inhibitor
• CAS No. 1254473-64-7
• Calculated MW 444.31
• Formulation C21H19Cl2N5O2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:C[C@H](C1=C(C=NC=C1Cl)Cl)OC2=CC3=C(C=C2)NN=C3/C=C/C4=CN(N=C4)CCO
  Pathways:Angiogenesis; Tyrosine Kinase/Adaptors
  Receptor:FGFR1; FGFR2; FGFR3; FGFR4; VEGFR2
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 57 mg/mL warmed (128.28 mM); DMSO: 88 mg/mL (198.05 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Zhao G, et al. Mol Y Ther. 2011, 10(11), 2200-2210.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting