• Product NameIrbinitinib(ARRY-380; ONT-380)
• Brief DescriptionInhibitors
• Purification99.96%
• Biological ActivityIrbinitinib(ARRY-380; ONT-380) is a potent and selective HER2 inhibitor with IC50 of 8 nM, equipotent against truncated p95-HER2, 500-fold more selective for HER2 versus EGFR.
• Target NameEGFR inhibitor; HER inhibitor
• CAS No. 937263-43-9
• Calculated MW 480.52
• Formulation C26H24N8O2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CC1=C(OC2=CC3=NC=NN3C=C2)C=CC(NC2=NC=NC3=C2C=C(NC2=NC(C)(C)CO2)C=C3)=C1
  Pathways:Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
  Receptor:EGFR; HER2/ErbB2; p95 HER2
  Boling pt:
  Melting pt:
  Solubility:DMSO: 10 mM
  Appearance:Yellow Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. P Lee, et al. Cancer Research(Poster Session Abstracts). 2009, 69(24 Suppl):Abstract nr 5104.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting