• Product NamePilaralisib (XL147)
• Brief DescriptionInhibitors
• Purification99.61%
• Biological ActivityPilaralisib (XL147) is a selective and reversible class I PI3K inhibitor for PI3Kα/δ/γ with IC50 of 39 nM/36 nM/23 nM in cell-free assays, less potent to PI3Kβ. Phase 1/2.
• Target NamePI3K inhibitor
• CAS No. 934526-89-3
• Calculated MW 541.02
• Formulation C25H25ClN6O4S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:COC1=CC(NC2=NC3=CC=CC=C3N=C2NS(=O)(=O)C2=CC=CC(NC(=O)C(C)(C)N)=C2)=C(Cl)C=C1
  Pathways:PI3K/Akt/mTOR signaling
  Receptor:PI3Kα; PI3Kβ; PI3Kγ; PI3Kδ
  Boling pt:
  Melting pt:
  Solubility:DMSO: 100 mg/mL warmed (184.83 mM)
  Appearance:Yellow Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Foster P, et al. Mol Y Ther. 2015, 14(4), 931-940.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting