• Product NameRociletinib (CO-1686, AVL-301)
• Brief DescriptionInhibitors
• Purification99.25%
• Biological ActivityCO-1686 is a novel, irreversible and orally delivered kinase inhibitor that specifically targets the mutant forms of EGFR including T790M(IC50=21 nM).
• Target NameEGFR inhibitor
• CAS No. 1374640-70-6
• Calculated MW 555.55
• Formulation C27H28F3N7O3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:COC1=C(NC2=NC=C(C(NC3=CC(NC(=O)C=C)=CC=C3)=N2)C(F)(F)F)C=CC(=C1)N1CCN(CC1)C(C)=O
  Pathways:Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
  Receptor:EGFR (L858R/T790M); EGFR (wt)
  Boling pt:
  Melting pt:
  Solubility:DMSO: 100 mg/mL (180.0 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Walter AO, et al. Y Discov. 2013 Sep 25.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting