• Product NameAP24534 Ponatinib
• Brief DescriptionInhibitors
• Purification99.58%
• Biological ActivityPonatinib (AP24534) is a novel, potent multi-target inhibitor of Abl, PDGFRα, VEGFR2, FGFR1 and Src with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM and 5.4 nM, respectively.
• Target NameBcr-Abl inhibitor; c-Kit inhibitor; FGFR inhibitor; PDGFR inhibitor; Src inhibitor; VEGFR inhibitor
• CAS No. 943319-70-8
• Calculated MW 532.56
• Formulation C29H27F3N6O
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cardiovascular System
  SMILES:CN1CCN(CC2=C(C=C(NC(=O)C3=CC(C#CC4=CN=C5C=CC=NN45)=C(C)C=C3)C=C2)C(F)(F)F)CC1
  Pathways:Angiogenesis; Tyrosine Kinase/Adaptors; Cytoskeletal Signaling
  Receptor:Abl; c-Kit; FGFR1; PDGFRα; c-Src; VEGFR2
  Boling pt:
  Melting pt:
  Solubility:DMSO: 30 mg/mL (56.33 mM)
  Appearance:Yellow Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. O'Hare T, et al. Y Cell, 2009, 16(5), 401-412.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting