• Product NameHTH-01-015
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityHTH-01-015 is a potent and selective NUAK1 inhibitor with IC50 of 100 nM, >100-fold selectivity over NUAK2.
• Target NameAMPK inhibitor
• CAS No. 1613724-42-7
• Calculated MW 468.55
• Formulation C26H28N8O
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:CN1C2=CC3=CC=CC=C3C=C2C(=O)N(C)C2=C(C)N=C(NC3=CN(N=C3)C3CCNCC3)N=C12
  Pathways:PI3K/Akt/mTOR signaling
  Receptor:NUAK1; NUAK2
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 30 mg/mL (64.02 mM); DMSO: 58 mg/mL warmed (123.78 mM)
  Appearance:Yellow Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Banerjee S, et al. Biochem J. 2014, 457(1), 215-225.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting