• Product NameZK-811752, BX-471
• Brief DescriptionInhibitors
• Purification99.94%
• Biological ActivityBX471 is a potent, selective non-peptide CCR1 antagonist (Ki = 1 nM for human CCR1); exhibits 250-fold selectivity for CCR1 over CCR2, CCR5 and CXCR4.
• Target NameCCR inhibitor
• CAS No. 217645-70-0
• Calculated MW 434.89
• Formulation C21H24ClFN4O3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Immunology
  SMILES:C[C@@H]1CN(CCN1C(=O)COC2=C(C=C(C=C2)Cl)NC(=O)N)CC3=CC=C(C=C3)F
  Pathways:Immunology/Inflammation; Microbiology&virology
  Receptor:human CCR1
  Boling pt:
  Melting pt:
  Solubility:DMSO: >51 mg/mL
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Liang M, et al. J Biol Chem. 2000 Jun 23;275(25):19000-8.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting