• Product NameXL147 analogue
• Brief DescriptionInhibitors
• Purification99.72%
• Biological ActivityXL147 analogue is a selective and reversible class I PI3K inhibitor for PI3Kα/δ/γ with IC50 of 39 nM/36 nM/23 nM in cell-free assays, less potent to PI3Kβ. Phase 1/2
• Target NameDNA-PK inhibitor; PI3K inhibitor
• CAS No. 956958-53-5
• Calculated MW 448.52
• Formulation C21H16N6O2S2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CC1=CC=C(C=C1)S(=O)(=O)NC1=NC2=CC=CC=C2N=C1NC1=CC2=NSN=C2C=C1
  Pathways:DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling
  Receptor:DNA-PK; PI3Kα; PI3Kβ; PI3Kγ; PI3Kδ
  Boling pt:
  Melting pt:
  Solubility:DMSO: 3 mg/mL (6.68 mM)
  Appearance:Yellow Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Chakrabarty A, et al. Proc Natl Acad Sci U S A, 2011, 1-6.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting