• Product NameRGB-286638 free base
• Brief DescriptionInhibitors
• Purification99.91%
• Biological ActivityRGB-286638 free base is a novel CDK inhibitor with IC50s of 1 nM/2 nM/3 nM/4 nM/5 nM for cyclin T1-CDK9/cyclin B1-CDK1/cyclin E-CDK2/cyclin D1-CDK4/cyclin E-CDK3/p35-CDK5 respectively; less potent against cyclin H-CDK7 and cyclin D3-CDK6.
• Target NameCDK inhibitor
• CAS No. 784210-88-4
• Calculated MW 545.63
• Formulation C29H35N7O4
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:COCCN1CCN(CC2=CC=C(C=C2)C2=NNC3=C2C(=O)C2=C3C=CC=C2NC(=O)NN2CCOCC2)CC1
  Pathways:Cell Cycle/Checkpoint
  Receptor:CDK1/cyclinB1; CDK2/cyclinE; CDK3/cyclinE; CDK4/cyclinD1; CDK9/cyclinT1; p35-CDK5
  Boling pt:
  Melting pt:
  Solubility:DMSO: 10 mM
  Appearance:Yellow Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Cirstea D, et al. Leukemia. 2013 Dec;27(12):2366-75.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting