• Product NameUNC1215
• Brief DescriptionInhibitors
• Purification99.04%
• Biological ActivityUNC1215 is a potent and selective MBT (malignant brain tumor) antagonist, which binds L3MBTL3 with IC50 of 40 nM and Kd of 120 nM, 50-fold selective versus other members of the human MBT family.
• Target NameEpigenetic Reader Domain antagonist
• CAS No. 1415800-43-9
• Calculated MW 529.72
• Formulation C32H43N5O2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:O=C(N1CCC(CC1)N1CCCC1)C1=CC(NC2=CC=CC=C2)=C(C=C1)C(=O)N1CCC(CC1)N1CCCC1
  Pathways:Chromatin/Epigenetic
  Receptor:L3MBTL3; L3MBTL3; L3MBTL3-D274A
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 100 mg/mL (188.77 mM); DMSO: 100 mg/mL (188.77 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. James LI, et al. Nat Chem Biol, 2013, 9(3), 184-191.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting