• Product NameVemurafenib (PLX4032, RG7204)
• Brief DescriptionInhibitors
• Purification98.40%
• Biological ActivityVemurafenib (PLX4032, RG7204) is a novel and potent inhibitor of B-RafV600E with IC50 of 31 nM in cell-free assay
• Target NameACK inhibitor; BTK inhibitor; MAPK inhibitor; MNK inhibitor; Raf inhibitor; Src inhibitor; Tyrosine Kinases inhibitor; Wnk inhibitor
• CAS No. 918504-65-1
• Calculated MW 489.92
• Formulation C23H18ClF2N3O3S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CCCS(=O)(=O)NC1=C(F)C(C(=O)C2=CNC3=NC=C(C=C23)C2=CC=C(Cl)C=C2)=C(F)C=C1
  Pathways:Angiogenesis; MAPK; Neuroscience; Others; Proteases/Proteasome; Tyrosine Kinase/Adaptors
  Receptor:ACK1; BLK; BRK; MAP4K5 (KHS1); NEK11; MNK2; B-Raf; B-Raf (V600E); C-Raf; SRMS; Lyn B; FGR; Lck; Src; Yes1; CSK; FRK (PTK5); WNK3
  Boling pt:
  Melting pt:
  Solubility:DMSO: 97 mg/mL (197.99 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Bollag G, et al. Nature, 2010, 467(7315), 596-599.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting