• Product NamePanobinostat (LBH589)
• Brief DescriptionInhibitors
• Purification97.20%
• Biological ActivityPanobinostat (LBH589) is a novel broad-spectrum HDAC inhibitor with IC50 of 5 nM in a cell-free assay. Phase 3.
• Target NameHDAC inhibitor
• CAS No. 404950-80-7
• Calculated MW 349.43
• Formulation C21H23N3O2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CC1=C(C2=CC=CC=C2N1)CCNCC3=CC=C(C=C3)/C=C/C(=O)NO
  Pathways:Chromatin/Epigenetic; DNA Damage/DNA Repair; NF-κb
  Receptor:HDAC (MOLT-4 cells); HDAC (Reh cells)
  Boling pt:
  Melting pt:
  Solubility:DMSO: 69 mg/mL (197.46 mM)
  Appearance:Yellowish-browns Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Scuto A, et al. Blood. 2008, 111(10), 5093-5100.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting