• Product NameVortioxetine
• Brief DescriptionInhibitors
• Purification97.92%
• Biological ActivityVortioxetine (Lu AA21004) is a multimodal serotonergic agent, inhibits 5-HT1A, 5-HT1B, 5-HT3A, 5-HT7 receptor and SERT with IC50 of 15 nM, 33 nM, 3.7 nM, 19 nM and 1.6 nM, respectively.
• Target Name5-HT Receptor modulator
• CAS No. 508233-74-7
• Calculated MW 298.45
• Formulation C18H22N2S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Nervous system
  SMILES:CC1=CC(C)=C(SC2=CC=CC=C2N2CCNCC2)C=C1
  Pathways:GPCR/G Protein; Neuroscience
  Receptor:5-HT1A; 5-HT1B; 5-HT3A; 5-HT7; SERT
  Boling pt:
  Melting pt:
  Solubility:DMSO, Ethanol: 200 mM
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Bang-Andersen B, et al. J Med Chem, 2011, 54(9), 3206-3221.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting