• Product NameVortioxetine (Lu AA21004) HBr
• Brief DescriptionInhibitors
• Purification99.89%
• Biological ActivityVortioxetine (Lu AA21004) is a multimodal serotonergic agent, inhibits 5-HT1A, 5-HT1B, 5-HT3A, 5-HT7 receptor and SERT with IC50 of 15 nM, 33 nM, 3.7 nM, 19 nM and 1.6 nM, respectively.
• Target Name5-HT Receptor inhibitor
• CAS No. 960203-27-4
• Calculated MW 379.36
• Formulation C18H22N2SHBr
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Nervous system
  SMILES:CC1=CC(=C(C=C1)SC2=CC=CC=C2N3CCNCC3)C.Br
  Pathways:GPCR/G Protein; Neuroscience
  Receptor:5-HT1A; 5-HT1B; 5-HT3A; 5-HT7; SERT
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 17 mg/mL (44.81 mM); DMSO: 76 mg/mL (200.33 mM)
  Appearance:WhitePowder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Bang-Andersen B, et al. J Med Chem, 2011, 54(9), 3206-3221.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting