• Product NameBromfenac sodium
• Brief DescriptionInhibitors
• Purification92.00%
• Biological ActivityBromfenac Sodium is the sodium salt form of bromfenac, a nonsteroidal anti-inflammatory drug (NSAID) with analgesic and anti-inflammatory activities. Upon ophthalmic administration, bromfenac binds to and inhibits the activity of cyclooxygenase II (COX II), an enzyme which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins (PG). By inhibiting PG formation, bromfenac is able to inhibit PG-induced inflammation, thereby preventing vasodilation, leukocytosis, disruption of the blood-aqueous humor barrier, an increase in vascular permeability and an increase in intraocular pressure (IOP).
• Target NameCOX inhibitor
• CAS No. 120638-55-3
• Calculated MW 356.15
• Formulation C15H11BrNNaO3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Nervous system
  SMILES:O.O.O.[Na+].NC1=C(C=CC=C1CC([O-])=O)C(=O)C1=CC=C(Br)C=C1
  Pathways:Immunology/Inflammation; Neuroscience
  Receptor:COX-2
  Boling pt:
  Melting pt:
  Solubility:DMSO: 10 mM
  Appearance:Yellow Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Shimura M, Yasuda K. Br J Ophthalmol. 2015 Feb;99(2):215-9.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting