• Product NameTAK-438(Vonoprazan fumarate)
• Brief DescriptionInhibitors
• Purification99.33%
• Biological ActivityVonoprazan Fumarate (TAK-438) is a novel P-CAB (potassium-competitive acid blocker) that reversibly inhibits H+/K+, ATPase with IC50 of 19 nM (pH 6.5), controls gastric acid secretion. Phase 3.
• Target NameATPase inhibitor
• CAS No. 1260141-27-2
• Calculated MW 461.46
• Formulation C17H16FN3O2SC4H4O4
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Immunology
  SMILES:CNCC1=CN(C(=C1)C2=CC=CC=C2F)S(=O)(=O)C3=CN=CC=C3.C(=C/C(=O)O)\C(=O)O
  Pathways:Membrane transporter/Ion channel
  Receptor:H+/K+-ATPase
  Boling pt:
  Melting pt:
  Solubility:DMSO: 62 mg/mL (134.35 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Arikawa Y, et al. J Med Chem, 2012, 55(9), 4446-4456.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting