• Product NameRevaprazan hydrochloride
• Brief DescriptionInhibitors
• Purification99.91%
• Biological ActivityRevaprazan Hydrochloride is the hydrochloride salt form of a lipophilic, weak base with potassium-competitive acid blocking (P-CAB) activity. Revaprazan concentrates highly in the gastric parietal cell canaliculus and on entering this acidic environment is instantly protonated and binds competitively and reversibly to the potassium binding site of the proton pump hydrogen-potassium adenosine triphosphatase (H+/K+ ATPase), thereby inhibiting the pump's activity and the parietal cell secretion of H+ ions into the gastric lumen, the final step in gastric acid production.
• Target NameATPase inhibitor
• CAS No. 178307-42-1
• Calculated MW 398.9
• Formulation C22H24ClFN4
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Immunology
  SMILES:CC1N(CCC2=CC=CC=C12)C1=NC(NC2=CC=C(F)C=C2)=NC(C)=C1C
  Pathways:Membrane transporter/Ion channel
  Receptor:H+/K+-ATPase
  Boling pt:
  Melting pt:
  Solubility:DMSO: 10 mM
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Lee JS, et al.J Clin Biochem Nutr. 2012 Sep;51(2):77-83.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting