• Product NameSRT1720
• Brief DescriptionInhibitors
• Purification98.76%
• Biological ActivitySRT1720 hydrochloride is a selective activator of human SIRT1 (EC1.5 = 0.16 μM) versus the closest sirtuin homologues, SIRT2 and SIRT3 (SIRT2: EC1.5 = 37 μMSIRT3: EC1.5 > 300 μM).
• Target NameSirtuin inhibitor
• CAS No. 1001645-58-4
• Calculated MW 506.22
• Formulation C25H24ClN7OS
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:Cl.O=C(NC1=CC=CC=C1C1=CN2C(CN3CCNCC3)=CSC2=N1)C1=NC2=CC=CC=C2N=C1
  Pathways:Chromatin/Epigenetic; DNA Damage/DNA Repair
  Receptor:SIRT1
  Boling pt:
  Melting pt:
  Solubility:DMSO: 38 mg/mL (75.09 mM)
  Appearance:Deep Brownness Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Milne JC, et al. Nature. 2007, 450(7170), 712-716.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting