• Product NameTorkinib (PP242)
• Brief DescriptionInhibitors
• Purification99.69%
• Biological ActivityTorkinib (PP242) is a selective mTOR inhibitor with IC50 of 8 nM in cell-free assays; targets both mTOR complexes with >10- and 100-fold selectivity for mTOR than PI3Kδ or PI3Kα/β/γ, respectively.
• Target NameDNA-PK inhibitor; Hck inhibitor; mTOR inhibitor; PDGFR inhibitor; PI3K inhibitor
• CAS No. 1092351-67-1
• Calculated MW 308.34
• Formulation C16H16N6O
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:CC(C)N1C2=C(/C(=C\3/C=C4C=C(C=CC4=N3)O)/N1)C(=NC=N2)N
  Pathways:DNA Damage/DNA Repair; Angiogenesis; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
  Receptor:DNA-PK; Hck; mTOR; PDGFR; p110δ
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 18 mg/mL (58.37 mM); DMSO: 62 mg/mL (201.07 mM)
  Appearance:Brownness Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Apsel B, et al. Nat Chem Biol, 2008, 4(11), 691-699.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting