• Product NamePP121
• Brief DescriptionInhibitors
• Purification99.67%
• Biological ActivityPP-121 is a multi-targeted inhibitor of PDGFR, Hck, mTOR, VEGFR2, Src and Abl with IC50 of 2 nM, 8 nM, 10 nM, 12 nM, 14 nM and 18 nM, also inhibits DNA-PK with IC50 of 60 nM.
• Target NameHck inhibitor; mTOR inhibitor; PDGFR inhibitor; Src inhibitor; VEGFR inhibitor
• CAS No. 1092788-83-4
• Calculated MW 319.36
• Formulation C17H17N7
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:NC1=NC=NC2=C1C(=NN2C1CCCC1)C1=CN=C2NC=CC2=C1
  Pathways:Angiogenesis; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
  Receptor:Hck; mTOR; PDGFR; Src; VEGFR
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 2 mg/mL (6.26 mM); DMSO: 64 mg/mL (200.4 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Apsel B, et al. Nat Chem Biol, 2008, 4(11), 691-699.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting