• Product NameBIX02189
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityBIX02189 is a selective inhibitor of MEK5 with IC50 of 1.5 nM, also inhibits ERK5 catalytic activity with IC50 of 59 nM in cell-free assays, and does not inhibit closely related kinases MEK1, MEK2, ERK2, and JNK2.
• Target NameERK inhibitor; MEK inhibitor; TGF-beta/Smad inhibitor
• CAS No. 1094614-85-3
• Calculated MW 440.54
• Formulation C27H28N4O2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:CN(C)CC1=CC(=CC=C1)N/C(=C\2/C3=C(C=C(C=C3)C(=O)N(C)C)NC2=O)/C4=CC=CC=C4
  Pathways:MAPK; Stem Cells
  Receptor:ERK5; MEK1; MEK2; MEK5; TGFβR1
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 80 mg/mL (181.59 mM); DMSO: 60 mg/mL warmed (136.19 mM)
  Appearance:Yellow Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Tatake RJ, et al. Biochem Biophys Res Commun, 2008, 377(1), 120-125.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting