• Product NameBMS794833
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityBMS-794833 is a potent ATP competitive inhibitor of Met/VEGFR2 with IC50 of 1.7 nM/15 nM, also inhibits Ron, Axl and Flt3 with IC50 of <3 nM; a prodrug of BMS-817378. Phase 1.
• Target Namec-Met/HGFR inhibitor; VEGFR inhibitor
• CAS No. 1174046-72-0
• Calculated MW 468.84
• Formulation C23H15ClF2N4O3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:NC1=NC=CC(OC2=C(F)C=C(NC(=O)C3=CNC=C(C3=O)C3=CC=C(F)C=C3)C=C2)=C1Cl
  Pathways:Angiogenesis; Tyrosine Kinase/Adaptors
  Receptor:Met; VEGFR2
  Boling pt:
  Melting pt:
  Solubility:DMSO: 94 mg/mL (200.49 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. WO2009094417A1

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting