• Product NamePHT-427
• Brief DescriptionInhibitors
• Purification99.50%
• Biological ActivityPHT-427 is a dual Akt and PDPK1 inhibitor (high affinity binding for the PH domains of Akt and PDPK1) with Ki of 2.7 μM and 5.2 μM, respectively.
• Target NameAkt inhibitor; PDK inhibitor
• CAS No. 1191951-57-1
• Calculated MW 409.61
• Formulation C20H31N3O2S2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:CCCCCCCCCCCCC1=CC=C(C=C1)S(=O)(=O)NC1=NN=CS1
  Pathways:Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
  Receptor:Akt; PDK1
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 60 mg/mL (146.48 mM); DMSO: 82 mg/mL (200.19 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Meuillet EJ, et al. Mol Y Ther, 2010, 9(3), 706-717.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting