• Product NamePHOB
• Brief DescriptionInhibitors
• Purification99.72%
• Biological ActivityHPOB is a potent, selective HDAC6 inhibitor with IC50 of 56 nM, >30-fold selectivity over other HDACs.
• Target NameHDAC inhibitor
• CAS No. 1429651-50-2
• Calculated MW 314.34
• Formulation C17H18N2O4
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:OCCN(C(=O)CC1=CC=C(C=C1)C(=O)NO)C1=CC=CC=C1
  Pathways:Chromatin/Epigenetic; DNA Damage/DNA Repair; NF-κb
  Receptor:HDAC1; HDAC10; HDAC3; HDAC6; HDAC8
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 38 mg/mL warmed (120.88 mM); DMSO: 62 mg/mL (197.23 mM)
  Appearance:Gray Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Lee JH, et al. Proc Natl Acad Sci U S A. 2013, 110(39), 15704-157099.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting