• Product NameEPZ011989
• Brief DescriptionInhibitors
• Purification98.32%
• Biological ActivityEPZ011989 is a potent, selective orally bioavailable EZH2 inhibitor with Ki < 3 nM for EZH2 wt and EZH2 Y646; 15-fold selectivity over EZH1 and >3000-fold selectivity over other HMTase.
• Target NameHistone Methyltransferase inhibitor
• CAS No. 1598383-40-4
• Calculated MW 605.81
• Formulation C35H51N5O4
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CCN(C1CCC(CC1)N(C)CCOC)C1=CC(=CC(C(=O)NCC2=C(C)C=C(C)NC2=O)=C1C)C#CCN1CCOCC1
  Pathways:Chromatin/Epigenetic
  Receptor:EZH2
  Boling pt:
  Melting pt:
  Solubility:DMSO: 10 mM
  Appearance:Yellow Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Campbell JE, et al. ACS Med Chem Lett. 2015 Mar 4;6(5):491-495.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting