• Product NameHMN214
• Brief DescriptionInhibitors
• Purification99.50%
• Biological ActivityHMN-214(IVX214) is a potent PLK1 inhibitor an average IC50 of 0.12 μM.
• Target NamePLK inhibitor
• CAS No. 173529-46-9
• Calculated MW 424.47
• Formulation C22H20N2O5S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CC(=O)N(C1=CC=CC=C1/C=C/C2=CC=[N+](C=C2)[O-])S(=O)(=O)C3=CC=C(C=C3)OC
  Pathways:Cell Cycle/Checkpoint
  Receptor:PLK1
  Boling pt:
  Melting pt:
  Solubility:DMSO: 12 mg/mL (28.27 mM)
  Appearance:Faint Yellow Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Garland LL, et al. Clin Y Res. 2006 Sep 1;12(17):5182-9.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting