• Product NameIC261
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityIC261 is a novel inhibitor of CK1, triggers the mitotic checkpoint control. The IC50 of IC261 for CK1 was 16 μM and for Cdk5 is 4.5 mM.
• Target NameCasein Kinase inhibitor; CDK inhibitor
• CAS No. 186611-52-9
• Calculated MW 311.33
• Formulation C18H17NO4
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:COC1=CC(OC)=C(C=C2C(=O)NC3=CC=CC=C23)C(OC)=C1
  Pathways:Metabolism; Cell Cycle/Checkpoint; Stem Cells
  Receptor:CK1; CDK5
  Boling pt:
  Melting pt:
  Solubility:DMSO: 10 mM
  Appearance:Yellow Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Behrend L, et al. Oncogene. 2000 Nov 9;19(47):5303-5313.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting