• Product NamePD184352 (CI-1040)
• Brief DescriptionInhibitors
• Purification98.31%
• Biological ActivityPD184352 (CI-1040) is an ATP non-competitive MEK1/2 inhibitor with IC50 of 17 nM in cell-based assays, 100-fold more selective for MEK1/2 than MEK5. Phase 2.
• Target NameMEK inhibitor
• CAS No. 212631-79-3
• Calculated MW 478.67
• Formulation C17H14ClF2IN2O2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:FC1=C(F)C(NC2=C(Cl)C=C(I)C=C2)=C(C=C1)C(=O)NOCC1CC1
  Pathways:MAPK
  Receptor:MEK1; MEK2
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 14 mg/mL (29.24 mM); DMSO: 96 mg/mL (200.55 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Sebolt-Leopold JS, et al. Nat Med, 1999, 5(7), 810-816.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting