• Product NameFG-2216
• Brief DescriptionInhibitors
• Purification99.50%
• Biological ActivityFG-2216 is a potent HIF-prolyl hydroxylase inhibitor with IC50 of 3.9 uM for PDH2 enzyme; orally bioavailable and induced significant and reversible Epo induction in vivo.
• Target NameHIF/HIF Prolyl-Hydroxylase inhibitor
• CAS No. 223387-75-5
• Calculated MW 280.66
• Formulation C12H9ClN2O4
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cardiovascular System
  SMILES:OC(=O)CNC(=O)C1=C(O)C2=CC=CC=C2C(Cl)=N1
  Pathways:Metabolism; Chromatin/Epigenetic
  Receptor:PHD2
  Boling pt:
  Melting pt:
  Solubility:DMSO: 10 mM
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Hong YR, et al. Bioorg Med Chem Lett. 2013 Nov 1;23(21):5953-7.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting