• Product NameKI8751
• Brief DescriptionInhibitors
• Purification99.90%
• Biological ActivityKi8751 is a potent and selective inhibitor of VEGFR2 with IC50 of 0.9 nM, >40-fold selective for VEGFR2 than c-Kit, PDGFRα and FGFR-2, little activity to EGFR, HGFR and InsR.
• Target Namec-Kit inhibitor; EGFR inhibitor; FGFR inhibitor; PDGFR inhibitor; VEGFR inhibitor
• CAS No. 228559-41-9
• Calculated MW 469.41
• Formulation C24H18F3N3O4
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:COC1=CC2=NC=CC(OC3=CC(F)=C(NC(=O)NC4=C(F)C=C(F)C=C4)C=C3)=C2C=C1OC
  Pathways:Angiogenesis; Tyrosine Kinase/Adaptors; JAK/STAT signaling
  Receptor:c-Kit; EGFR; FGFR2; PDGFRα; VEGFR2
  Boling pt:
  Melting pt:
  Solubility:DMSO: 47 mg/mL (100.12 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Kubo K, et al. J Med Chem, 2005, 48(5), 1359-1366.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting