• Product NameAZD7545
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityAZD7545 is a potent PDHK inhibitor with IC50 of 36.8 nM and 6.4 nM for PDHK1 and PDHK2, respectively.
• Target NameDehydrogenase inhibitor
• CAS No. 252017-04-2
• Calculated MW 478.87
• Formulation C19H18ClF3N2O5S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Metabolism system
  SMILES:C[C@@](C(=O)NC1=C(C=C(C=C1)S(=O)(=O)C2=CC=C(C=C2)C(=O)N(C)C)Cl)(C(F)(F)F)O
  Pathways:Metabolism
  Receptor:PDHK1; PDHK2
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 95 mg/mL (198.38 mM); DMSO: 95 mg/mL (198.38 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Morrell JA, et al. Biochem Soc Trans. 2003, 31(Pt 6), 1168-1170.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting