• Product NameSANT-1
• Brief DescriptionInhibitors
• Purification99.50%
• Biological ActivitySANT-1 directly binds to Smoothened (Smo) receptor with Kd of 1.2 nM and inhibits Smo agonist effects with IC50 of 20 nM.
• Target NameHedgehog/Smoothened antagonist
• CAS No. 304909-07-7
• Calculated MW 373.49
• Formulation C23H27N5
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:CC1=C(C(=NN1C2=CC=CC=C2)C)/C=N/N3CCN(CC3)CC4=CC=CC=C4
  Pathways:GPCR/G Protein; Stem Cells
  Receptor:Smoothened
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 20 mg/mL (53.54 mM); DMSO: 21 mg/mL (56.22 mM)
  Appearance:Yellow Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. James K. Chen, et al. Proc Natl Acad Sci U S A, 2002, 99(22), 14071-14076.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting